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Fibrodysplasia Ossificans Progressiva is a rare, disabling genetic diseases that affects 1 in 2 million people. There are 700 confirmed cases in the world and 235 of those are in the United States. Fibrodysplasia Ossificans Progressiva is where extra sheets of bone slowly forms in the muscles, ligaments, and tendons. The extra bone causes the effected person to slowly be frozen inside their skeleton. Early symptoms include deformed big toes, and large toes because of the extra bone growth. Another symptom is tender bumps on the victims back, which is also extra bone growth. Fibrodysplasia Ossificans Progressiva is highly misdiagnosed as cancer. The gene that causes this fatal disease was just discovered in April 2006 at the only laboratory in the US dedicated to FOP research, University of Pennsylvania School of Medicine. This gene is the ACVR1 gene. A small mutation in one of the two copies of the ACVR1 gene changes the meaning of its genetic message, so a defective protein is made. Only 1.5 million dollars are donated to this cause per year, which is a meager amount in the field of medicine.
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What are treatments for Fibrodysplasia Ossificans Progressiva?
there is no treatment
What does Fibrodysplasia Ossificans Progressiva have to do with the muscular system?
Fibrodysplasia Ossificans Progressiva causes uncontrolled growth of bone. Basically a second skeleton forms making movement restricted and eventually impossible, and bone forms in muscle, ligaments, and ligaments.
Does Fibrodysplasia Ossificans Progressiva have a bad chromosome?
The gene that is mutated in a person who has Fibrodysplasia Ossificans Progressiva is called the ACVR1 gene. A small mutation in one of the two copies of the ACVR1 gene modifies the meaning of its genetic message, so a defective protein is made.
What has the author Erwin Uehlinger written?
Erwin Uehlinger has written: 'Myositis ossificans progressiva' -- subject(s): Muscles, Diseases, Musculoskeletal system
What is the worst bone disease?
According to my suggestions, Osteoporosis is the worst bone disease. Bone cancer is bad
What is fibrodisplasia?
Fibrodysplasia ossificans progressiva (FOP) is a very rare disease of connective tissue. A mutation of the body's repair mechanism causes fibrous tissue like muscles, tendons, and ligaments) to be ossified, or made into bone, when damaged. Joints may become permanently immovable.
How many deaths have there been due to FOP disease?
Fibrodysplasia ossificans progressiva (FOP) is an extremely rare genetic disorder -- only occurring in 1 out of 2 million people. Given its rarity, only a few thousand people have had it and have died from it.See the related links section for a link to more information about FOP.
Common ailments of muscular system?
Muscular Dystrophy, Cerebral Palsy,Fibrodysplasia Ossificans Progressiva, Dermatomyositis,Compartment Syndrome,Myasthenia Gravis, Amyotrophic Lateral Sclerosis, Mitochondrial Myopathies,Rhabdomyolysis,Polymyositis,Fibromyalgia,Myotonia,Myofascial Pain Syndrome and etc.
When was the disease FOP discovered?
The medical community had recorded some cases that were likely this disorder as far back as the 1800's. It was described as a disease that causes people to "turn into stone". It became more well known in the 1970's with the treatment and eventual death of a patient with the extremely rare genetic disorder who donated his body to science. The gene that causes the progressive ossification of soft tissue to bone, was identified in 2006. It is called FOP disease because the medical name is Fibrodysplasia Ossificans Progressiva. For more information from WikiPedia on FOP, see the related links section below.
What has the author Rudolf Schoen written?
Rudolf Schoen has written: 'Polyarthritis chronica progressiva' -- subject(s): Arthritis deformans 'Adolf Windaus zum Gedenken' 'Biochemical findings in the differential diagnosis of internal diseases' -- subject(s): Biochemistry, Diagnosis
What is calcium buildup in muscle called?
Calcification in soft tissue, such as muscle, is called 'Calcinosis'. If it progresses into ossification (which involves the orderly deposition of calcium), it is called 'myositis ossificans'. However, the condition can occur in other connective tissue as well and may result from any kind of injury, including but not limited to inflammation. The term 'heterotropic ossification' has been proposed to replace it.
What has the author J Ramsay Hunt written?
J. Ramsay Hunt has written: 'Dyssynergia cerebellaris progressiva' -- subject(s): Cerebellum, Tremor, Diseases 'A theory of the mechanism underlying inhibition in the central nervous system' -- subject(s): Central nervous system, Contact inhibition (Biology) 'Pathological study of a case of myxoedema associated with tuberculosis of the adrenals' -- subject(s): Myxedema, Case studies
