Lissencephaly is a neurological disorder of early brain development that leads to the gross appearance of a smooth brain. The malformed brain lacks the characteristic convolutions of the normal cerebral cortex and is abnormally thick
Type I, also known as classical lissencephaly, is distinguished by the smooth surface of the cerebral cortex and an abnormal four-layered cortex. Classical lissencephaly can be associated with...
Diagnosis is usually made by neuroimaging. A computer tomography (CT ) or magnetic resonance imaging (MRI) scan shows a smooth brain with the lack of characteristic folds. MRI may delineate the band...
Type I lissencephaly is more common and comprises 43% of lissencephaly syndromes in some studies. Type II lissencephaly accounted for 14% of lissencephalies
There is no known cure for lissencephaly. Most individuals will die at an early age due to failure to thrive or infections such as pneumonia. Patients with milder forms such as double cortex syndrome...