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Zeisel's method is used to estimate the alkoxy linkages in an organic compound. In this method the organic compound containing alkoxy group is treated with hydrogen iodide and the alkyl halide formed is further treated with silver nitrate to precipitate silver iodide
In this reaction only hydrogen iodide can be used because it consists of an ionic bond, while HF, HCl, HBr contain covalent bond where an iodide ion is liberated which forms a precipitate with silver nitrate. The silver iodide can be weighed and from its weight the number or alkoxy group can be estimated.
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