Category C: No adequate human or animal studies, or adverse fetal effects in animal studies, but no available human data
Category A: Controlled human studies have demonstrated no fetal risk.
Category B: Animal studies indicate no fetal risk, but no human studies, or adverse effects in animals, but not in well-controlled human studies.
Category D: Evidence of fetal risk, but benefits outweigh risks
Category B: Animal studies indicate no fetal risk, but no human studies; or adverse effects in animals, but not in well-controlled human studies.
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