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Lungs
A bleb is due to the rupture of the wall of the alveolus, allowing air to escape into the alveolar layer of the pleura.
With a bulla, there is distention of the alveoli with atrophy, followed by rupture and the formation of an unusually large air filled cavity.
Blebs and bullae can be single, multiple, small or distended enough to occupy an entire hemithorax. Frequently bilateral and usually associated with a generalized pulmonary emphysema.
Note: The majority of emphysematous blebs are caused by cigarette smoking.
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