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Analytical chromatography refers to the processes of separating a sample into its components and identifying these components, and is usually a small scale process. Preparative chromatography, on the other hand deals with isolating the separated components of a sample, and can be done on both small-scale or larger industrial scale operations. Preparative chromatography is a form of purification that utilizes chromatography.

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Q: What is difference between preparative and analytical chromatography?
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GCMS involves running the sample through a mass spectrometer following the data received from chromatography. MS fragments the analytes to show patterns specific to the analyte (and the ionization technique and sector powers) therefore allowing the analyte to be identified. GC is used to separate all volatile substituents of a sample so they can be identified one by one.


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The partition chromatography involves separation between liquids while adsoption chromatography involves solid and liquid separations. Answer: Partition Chromatography is a liquid liquid extraction which involves two solvents while adsorption chromatography is a liquid solid extraction which involves a solid stationary phase & a liquid mobile phase.


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Flash chromatography uses pressure (under 10 psi) to pump solvent down a column at a rate faster than gravity would provide. Vacuum chromatography uses a vacuum at the bottom of the column to pull solvent through. Both can be performed with standard glass columns, but usually vacuum chromatography is done with a silica filled vacuum funnel instead as a rough purification technique.

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