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What is importance of hemoglobin H?

Updated: 8/17/2019
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Hemoglobin H disease is a type of Thalassemia.

Thalassemia is a genetic (inherited) disorder, affecting the haemoglobin's structure, more precisely, the protein chains of the haemoglobin, which are responsible for carrying the oxygen and carbon dioxide inside the Red Blood Cells. If any of these protein chains is defective, the haemoglobin's ability to bind to (carry) the oxygen/carbon dioxide is hindered.

The two kind of protein chains are:

Beta globin chain = needs one gene per parent, and

Alpha globin chain = needs two genes per parent.

In Hemoglobin H disease the Alpha globin chains are affected, namely, three genes (one from one parent and 2 from the other parent) are defective (missing). That results in insufficiant oxygenation of the tissues, - anaemia -, ranging from moderate to severe.

More information could be found at related links.

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