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Acetaminophen (Tylenol) passes though the liver, while ibuprofen (Motrin) is passed through your kidneys. You can take your dosage (based on your weight ) for either medications at the same time safely.

As a PA in the pediatric ER we do tell parents that they can give their child BOTH Tylenol and Motrin to help fight a bad fever. We like to have them have some overlap time because then the fever is covered (Take Tylenol 1st and 2 hours later take Motrin). Most of the time we just suggest straight Motrin (more than Tylenol) because the overlap can be confusing and their is a higher risk of Tylenol overdose than with Motrin. Remember Asprin (Acetylsalicylic acid) is different than Motrin/Advil (Ibuprofen) and Tylenol (Acetaminphen) and should NOT be given to children because it can cause Reyes Syndrome.

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12y ago
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14y ago

you can take maximum dosage of both drugs (according to age of patient) as stated on the packs. there are no drug interactions between ibuprofen and paracetamol so they are safe to take together. however, gastric pain can be a side effect so do not take these tablets on an empty stomach and try not to stay on this combination for a prolonged period of time.

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Q: What is maximum dose of ibuprofen and acetaminophen when taken together?
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