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What is polychromasia?

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polychromasia: the reaction of red cells to stain as indicated by the appearance of bluish or grayish colored erythrocytes

Polychromasia refers to variation in erythrocyte coloration. This variation largely relates to the maturation of the cell. The younger form will appear with bluer cytoplasm in Romanowsky stains; the mature form will stain uniformly orange-pink. No standardized index of avian polychromasia is being employed clinically. A slight degree of polychromasia is normal. Increases in polychromasia suggest an increased bone marrow response. No polychromasia correlates with non-responsive, anemic patients, which is characterized by all cells exhibiting the same coloration. This finding presents a guarded prognosis, pending resolution of the cause of the non-regeneration.

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