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Polymicrogyria (PMG) is a condition characterized by abnormal development of the brain before birth. The surface of the brain normally has many ridges or folds, called gyri. In people with polymicrogyria, the brain develops too many folds, and the folds are unusually small.

Polymicrogyria can affect part of the brain or the whole brain. The signs and symptoms associated with polymicrogyria depend on how much of the brain, and which particular brain regions, are affected.

Researchers have identified multiple forms of polymicrogyria. Individuals with polymicrogyria can enjoy a fulfilling, rich life with range of abilities, feelings, talents and interests, but also face physical and cognitive challenges related to PMG. Since each presentation of PMG is unique to the individual, a physician with experience treating PMG is the best resource for information about prognosis and treatment.

(Material sourced from: The National Institute of Health - U.S. Government)

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