What is the LD50 for acetaminophen?

Answer 1

I hear its around 800 milligrams per kilogram of body weight, I weigh 64 kg so its around 51200 g of acetaminophen to kill me, but small doses over a large period of time can cause severe liver damage.

The Tylenol bottles always say "It is hazardus to exceed 4,000mg (4 grams) unless advidesd by a doctor. So if you take say, 10,000mg (10 grams) you would probably have sever liver damage, or even worse, liver failure.

Answer 2

I believe the answer is 1.3 x 10^3 pills/hour.

As a toxicologist and medical student, i do not understand that answer so I'll add that

the drug databank (maintained via university of Alberta) lists it only for mice/rats but does report that liver failure in people(that would be fairly lethal, eh?) has occured at daily doses of 4000mg. Ld 50 mean some die early and others late as levels increase so fatal for some is maybe only moderate damage for others.

Answer 3

The LD50 of hydrocodone (Vicodin) is irrelevant because the amount of acetaminophen in the pills would kill you more quickly, and more horribly. The LD50 for acetaminophen, which can be between 90-99% of the Vicodin pill, has been estimated at ranges between 330 and 2000 mg/kg, although liver failure has been observed in adults at doses as low as 6 g (according to Canadian Drugbank website, linked below).

Answer 4

The previous poster's information is incorrect. The acetaminophen poisoning that would result would indeed be lethal, and horribly so, at a dose that would be lethal in terms of hydrocodone; however, the narcotic lethality of hydrocodone is MUCH faster than the liver toxicity of acetaminophen.

Answer 5

Oral LD50: 636mg/kg (rat), 740 mg/kg (mouse), 495 mg/kg (guinea pig).

See you Pawel

Answer 6

4.5 GRAMS/KG (That's 4500mg/kg) for a rat

1.85 GRAMS/KG (That's 1850mg/kg) for a mouse

Seems you'd be hard-pressed to die by way of overdose...

Answer 7

375mgs in a rat LD50 ...per kilogram

Answer 8

6,000 mg