answersLogoWhite

0


Best Answer

Missense mutation: changes one sense codon to another, resulting in incorporation of amino acid.

Nonsense mutation: changes a sense codon into a stop (or nonsense) codon, resulting in premature termination.

User Avatar

Wiki User

14y ago
This answer is:
User Avatar
More answers
User Avatar

Wiki User

15y ago

A frameshift mutation is when there is an addition or a deletion of a base pair in the DNA sequence. When the mRNA is then being translated, it is misread because the reading frame is shifted by an extra base, hence frame shift mutation.

A nonsense mutation is when on of the codons is mutated at form a termination codon (UAG, UAA or UGA). It leads to pre-mature termination of the polypeptide.

This answer is:
User Avatar

Add your answer:

Earn +20 pts
Q: What is the difference between a nonsense mutation and a missense mutation?
Write your answer...
Submit
Still have questions?
magnify glass
imp
Continue Learning about Natural Sciences

What are the similarities of a nonsense mutation and a missense mutation?

Both nonsense and missense mutations are point mutations - meaning a single base has been substituted. The difference between the two is that a missense mutation results in an amino acid being replaced with a different amino acid, whereas a nonsense mutation results in a premature stop codon.


What will happen if there was a change in the base pair sequence?

Changing a base pair on a human chromosome (or any organism's chromosome) can range from no effect to catastrophic. The changing of a base pair -- a mutation -- can either result in a nonsense mutation, a missense mutation, or a silent mutation.A nonsense mutation changes a codon upstream of the normal stop codon into a stop codon, resulting in a truncated protein. Such proteins are non-functional and usually result in a non-viable offspring although some can survive (with serious genetic disorders).A missense mutation is just like a nonsense mutation, except the codon isn't changed into a stop codon and the protein does not terminate early. The only difference between the normal protein and the affected protein is that the affected protein will have one amino acid along the polypeptide chain that is different. The affects of such a change can change the shape of the protein entirely, seen with sickle-cell anemia.A silent mutation has no effect on the protein produced. There are only 20 amino acids, but 43 variations of four bases arranged three at a time (in other words, there are 64 different codons possible). Accordingly, more than one codon can code for the same amino acid. For example, both UAU and UAC code for the amino acid tyrosine. Imagine a point mutation replaced the U in UAU with a C making it UAC. Either way, the amino acid that will be used will be tyrosine, in no way changing the structure of the protein. For that reason, these mutations are "silent" or having no effect.


What is the difference between Sense and Nonsense?

sense means- with sense and nonsense means- little no sense or meaning I realy do hope it helps you.


What is the Difference between a mutant and mutation?

A mutagen is a substance that CAUSES a mutation. Essentially, mutagens are the cause, mutations are the effect. Simple as that :)


What is the difference between helpful and harmful mutation?

a beneficial mutation in an animal, plant, cell or bacteria will allow it to have a better chance of survival and allow it to continue passing on its DNA in its offspring. a harmful mutation does the exact opposite it hinders the animals survival and will eventually lead it's species to extinction.

Related questions

What are the similarities of a nonsense mutation and a missense mutation?

Both nonsense and missense mutations are point mutations - meaning a single base has been substituted. The difference between the two is that a missense mutation results in an amino acid being replaced with a different amino acid, whereas a nonsense mutation results in a premature stop codon.


What is the difference between a variation and a mutation?

mutation is an alteration in the nucleotide sequence of a gene whereas variation is any difference between individuals of a particular species.


What will happen if there was a change in the base pair sequence?

Changing a base pair on a human chromosome (or any organism's chromosome) can range from no effect to catastrophic. The changing of a base pair -- a mutation -- can either result in a nonsense mutation, a missense mutation, or a silent mutation.A nonsense mutation changes a codon upstream of the normal stop codon into a stop codon, resulting in a truncated protein. Such proteins are non-functional and usually result in a non-viable offspring although some can survive (with serious genetic disorders).A missense mutation is just like a nonsense mutation, except the codon isn't changed into a stop codon and the protein does not terminate early. The only difference between the normal protein and the affected protein is that the affected protein will have one amino acid along the polypeptide chain that is different. The affects of such a change can change the shape of the protein entirely, seen with sickle-cell anemia.A silent mutation has no effect on the protein produced. There are only 20 amino acids, but 43 variations of four bases arranged three at a time (in other words, there are 64 different codons possible). Accordingly, more than one codon can code for the same amino acid. For example, both UAU and UAC code for the amino acid tyrosine. Imagine a point mutation replaced the U in UAU with a C making it UAC. Either way, the amino acid that will be used will be tyrosine, in no way changing the structure of the protein. For that reason, these mutations are "silent" or having no effect.


What is the difference between mutation and variation?

variation is difference between genes and trait among individual* organism within population. mutation is change in genetic instruction I hope it helps


What is the difference between Sense and Nonsense?

sense means- with sense and nonsense means- little no sense or meaning I realy do hope it helps you.


What is a difference between a gene mutation and a chromosomes mutation?

a gene is passed on from generations and a chromosome is just found in certain cells


What is the Difference between a mutant and mutation?

A mutagen is a substance that CAUSES a mutation. Essentially, mutagens are the cause, mutations are the effect. Simple as that :)


What is the difference between crossover and mutation in genetic algorithm?

mutation means change in genetic structure..where as crossover means interchanging the genetic structure of two or more chromosomes..


What is the difference between Hanukkah and chankah?

The difference is that One is a Jewish Holiday and the other is a nonsense word. The only two standard spellings are Hanukkah and Chanukah.


Which is not a difference between a population showing exponential growth and a population showing logistic growth?

Mutation Rate


What is mutation and how many types of mutaion are there?

A mutation is any change in the DNA sequence. This list probably isn't exhaustive, but the types I can think of are: point (one basepair is changed into another) deletion (one or more basepairs is removed) insertion (one or more basepairs is added to the DNA sequence) translocation (a segment of DNA is moved from one region to another) duplication (a region of DNA is... well duplicated... some regions of DNA, particularly repetitive regions are often subject to extensive expansion) If you want to get really technical there are lots of subtypes and terminology used to describe mutations. A point mutation could also be termed a lot of other things, particularly if it is in a stretch of coding DNA (silent, missense, and nonsense mutations) and can be further subdivided by whether it's a change between a purine and a purine (transition mutation), a pyrimidine and pyrimidine (also a transition mutation), or a purine and a pyrimidine (transversion mutation).


What is the difference between helpful and harmful mutation?

a beneficial mutation in an animal, plant, cell or bacteria will allow it to have a better chance of survival and allow it to continue passing on its DNA in its offspring. a harmful mutation does the exact opposite it hinders the animals survival and will eventually lead it's species to extinction.