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Differential centrifugation: The solution (eg sucrose) is uniform throughout the test tube. You separate organelles based on their size and density.

Density gradient centrifugation: There is a gradient of concentration of solution throughout the test tube. The concentration of sucrose is minimal at the top of the tube and maximal at the bottom of the tube. This type of centrifugation separates organelles by density only.

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Q: What is the difference between density gradient and differential centrifugation?
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