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The salt forms, "hydrochloride" and "pamoate," are distinguishable by the release mechanism properties. Additionally, in the retail pharmacy setting, hydroxyzine hydrochloride is manufactured as a tablet whereas hydroxyzine pamoate comes in the capsule form. This is obviously a general answer for a much more elaborate explanation.

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15y ago
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10y ago

The hydrochloride salt is used in tablet form and pamoate is used in capsules. It may be either a stability concern or masking of taste of pamoate. I do not think it would cause any adverse reaction if somebody replaces the dosage form.

As stated above there Is no "real" difference between the two medicines. HLC and Pamoate are simply different versions of "salt"

I would suggest giving half dose at first, Just to be safe. But I would probably say that a 1:1 switch Is fine.

If you're asking can you take them together - the answer is NO because they're the same medication.

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Q: What is the difference if any between hydroxyzine hcl and hydroxyzine pamoate hcl?
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