What is the role of calcium in synaptic activity?

Answer 1

In a classic synapse, calcium's main role is to trigger the release of chemicals (called neurotransmitters) from the presynaptic neuron. How calcium does this is well established and is achieved through voltage-gated calcium channels located on the membrane of the presynaptic terminal. These channels open in response to membrane depolarization, the type of signal carried by an action potential.

The whole process goes something like this: When an action potential arrives at the presynaptic terminal, it depolarizes the membrane sufficiently to open voltage-gated calcium channels. The calcium gradient across the membrane is such that when these channels open, an inward calcium current is produced, with calcium rapidly entering the cell. Calcium is rapidly bound by a presynaptic intracellular protein called synaptotagmin. Synaptotagmin is considered a calcium sensor that triggers a host of downstream events. Ultimately, synaptotagmin activation results in the fusion of neurotransmitter vesicles with the presynaptic membrane. These vesicles fuse with the membrane through interactions between v- and t-snares (the "v" and "t" stand for "vesicular" and "target", respectively) causing the release of neurotransmitters into the space between the pre- and postsynaptic terminal. Individual molecules of neurotransmitter diffuse across this space, called the synaptic cleft, and ultimately bind to receptors on the postsynaptic cell membrane.

Since calcium triggers the conversion of an electrical signal (the action potential) into a chemical one (the release of neurotransmitters), calcium can be thought of as the trigger for electrochemical transduction (the term literally means the conversion of electrical into chemical information).

Note that calcium's role is not limited to the presynaptic terminal; plenty of other synaptic phenomena rely on calcium. For example, at the specialized synapses between neurons and muscle cells (called the neuromuscular junction), binding of the neurotransmitter acetylcholine to the muscle cell triggers a rise in calcium within the muscle cell, which ultimately leads to muscle contraction. Another example occurs in the brain and involves a postsynaptic receptor called the NMDA receptor. Activation of this receptor also produces a rise in intracellular calcium in the postsynaptic cell which contributes to a number of interesting phenomena, notably learning and memory.

Answer 2

Calcium ions cause vesicles containing neurotransmitters to fuse with the cell membrane, thus RELEASING the neurotransmitters into the synaptic cleft.

The vesicles in the axon terminal are like little water balloons, with a "skin" like the cell membrane. The Calcium ions have entered the axon terminal as a consequence of a neural impulse reaching the axon terminal and causing Calcium ion pores to open.

When the neurotransmitters reach the next neuron across the synapse, they open Sodium ion pores there, which initiate the continued propagation of the neural impulse through that neuron.

Answer 3

Calcium influx into the synaptic terminal causes vesicle fusion.

According to AP mastering it is...

Calcium enters the presynaptic cell and causes the release of ACh

Answer 4

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Answer 5

Calcium in necessary for the release of neurotransmitters.