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From: http://high-fat-nutrition.blogspot.com/2006/12/which-drink-causes-gout.HTMLWhich drink causes gout?Uric acid is a breakdown product of the purines, adenine and guanine. These compounds are found in relatively high amounts in meat, especially organ meats. Obviously, anyone with gout should avoid dietary sources of purines. Ah, if only life were so simple! It reminds me of the truism that eating fat makes you fat... If that were true your average dietician would have cured the current obesity epidemic easily by now.

No, gout is much more interesting.

Gout is triggered by the presence of crystals of uric acid in your joints. It extremely painful. Many people with gout have high levels of uric acid in their blood stream. Oddly enough some people with gout do not have high levels of uric acid in their blood. Dig deeper.

Fructose is an unusual sugar for humans to eat. We have no system to break down fructose polymers. The only sources of fructose we can use are the simple sugar in fruit or honey and as the molecule combined with glucose as sucrose, ie table sugar. Drenching your metabolism with fructose is a recent innovation for humans. The current preferred sweetener for soft drinks is "high fructose corn syrup", a product of our dearly beloved food industry in the last thirty years or less.

What happens when you drench you metabolism with fructose? It enters the metabolic pathway of carbohydrate below its main control step and is immediately converted to fructose-1-phosphate. Quite why evolution has arranged things this way is a mystery, but my suspicion is that evolution does not like free fructose in human metabolism. So drinking a small bucket of cola will put 100gm of fructose in to your liver. This will require a large input of phosphate to for the fructose-1-phosphate, leaving very little for the generation of adenosine tri phosphate (ATP), the primary energy currency of our cells. A lack of ATP triggers activity of the degradation system for adenine and the production of, guess what, uric acid! Gout, and not a serving of kidneys in sight. Until 100 years ago only the rich could afford enough sugar to get gout, now it is a feature of metabolic syndrome and available to all.

Incidentally the fructose has to be "put" somewhere, and that is in to fat for storage, via elevated triglyceride levels in the blood. It causes insulin resistance too. Even the full metabolic syndrome!

In fact, probably the truth is that fructose causes insulin resistance, which causes gout. The hyper uricaemia and the fact that the joints produce uric acid crystals do not have to be causally related. I'd say they're not.

Incidentally, these bright researchers are looking for ways to minimise the self poisoning caused by fructose. They are actually suggesting looking for a drug to allow you to drink high fructose corn syrup without the rise in uric acid.

A drug for life to enjoy your cola. But of course that won't stop the insulin resistance from fructose, so......

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Q: What is the importance of fructose in gout?
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Related questions

Is Coca-Cola bad for gout?

Yes , it is very bad!! Anything that contains high levels of fructose (such as high-fructose corn syrup) is bad for gout.


Does cinnamon powder and honey help gout?

the major constituent of honey is fructose. a recent study showed that people that drank drinks containing fructose had a higher risk of gout. the risk was comparable to 30 -50 ml of alcohol


Are there any treatments for gout?

To prevent gout, try reducing the intake of meat and seafood, alcohol and fructose while avoiding obesity. Treatments for gout are all drug-related, including NSAIDs and steroids, but for minor pain your Mother can try applying ice for 20 to 30 minutes at a time.


Where would one get a holistic cure for gout?

Dr. Well is a website with this type of cure for gout. Gout Treatment Site is another that claims different types of cures. There are help videos on YouTube showing beneficial treatments as well.


Can eating corn cause gout?

Corn isn't listed as a high or low purine content food. I would be mostly concerned with the type of corn he is eating, on the cob or out of the can. If it is canned corn then check the ingredients for how much sugar he is consuming. Anything with fructose syrup can trigger a gout flare.


I am from India my mother have high uric acid in her left leg she takes medicines prescribed by doctor but can anybody tell what food she should avoid and what to take to get rid of this disease?

High uric acid is a condition known as gout. Diet is not a treatment for gout, but can help you to control the attacks. People with gout should restrict their consumption of foods high in purines. These foods include meats, saturated fat, alcohol, and foods sweetened with high fructose corn syrup.


Does dexamethsone cure gout?

There is no cure for gout.


Gout in women?

Women can get gout however it is far more prevalent in men.


What molecule is fructose?

no fructose is not a molecule


Is fructose an electrolyte?

no, fructose is a sugar.


Does red or white wineaffect gout?

Wines will increase the risk of having a gout attack if you have a predisposition to gout.


Can a 30 year old female get gout?

Gout is unusual in females before menopause but yes they can get gout.