What is the largest breed of domestic cat?

Yes, it is possible, however if they are not in breeding season it is most likely that the wild cat will kill the domestic cat. But yes.

yes but it is not recommended

All around the Savannah is the largest domesticated cat as it is a hybrid between an African Wildcat and domesticated cat (the first being a Siamese). Another very large domesticated cat is the male...

The largest cat was a Maine Coon. It measured 48 inches which is equivalent to 4 ft. The Maine Coons are also the largest cat breed. The Savannah cat breed is the second largest cat breed.

Savannah, on average as big as a cocker spaniel.