pKa1 = 2.16
pKa2 = 8.05
Ref: Newton, D.W., Murray, w.j., Lovell, M.W. pKa Determination of benzhydrylpiperazine antihistamines in aqueous and aqueous methanol solutions (1982) Journal of Pharmaceutical Scienses 71 (12), pp. 1363-1366
can you take cyclizine hydrochloride when pregnant?
pKa=40
how do you calculate pKa
pKa=2.86
Cyclizine is used for motion sickness and vomiting. It is taken 30 minutes before departure and can be repeated every four to six hours as needed.
pKa = 15
It is around pKa=13
Doxofylline Pka value is about 9.8.
pKa (dissociation constant) is variable with temperature.
the only difference i found was that meclizine is not given to < 12 year old, only to 12 and older. cyclizine is given to age 6-12 and not <6 years old.
The pka of a protonated ether (the conjugate acid) is about -3.5
The pKa of sulfonic acid is < 0