Wolves, foxes, lynxes, and grizzly bears. Migrating Herds are oftenattacked by packs of wolves as the heard under attack scatters they will pick out the the oldest, weakest the youngest or pregnant animals. young calves may be attacked by eagles and Mosquitoes are also a serous problem for caribou. Swarms of them enter their noses, ears, and eyes in search of their blood and make life miserable for them.
They are traditionally hunted by the Inuit Eskimo who use them to make food clothes and tools.
Humans are also responsible for many of them being killed for sport.
the encroachment of human habitat industry and pollution of various kinds in the Arctic region are also increasingly killing of the caribou.
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Golden eagles who are non-nesting sub-adults are the most important predator of the calves on the calving grounds.They kill the calves with their talons. Wolves can be an important predator of adult caribou in the winter. Grizzly bears are found on both the summer and winter ranges of the Porcupine caribou. Wolverine are capable of killing a newborn calf or a cow giving birth. They also will take a sick or dying caribou. Blood-sucking insects are often called "micro-predators." Both mosquitoes and black flies bite persistantly and can prevent caribou from feeding, calves from nursing and even cause injuries by caribou rushing wildly about. Foxes, ravens, owls,haegars and hawks are other carrion eaters or scavengers that feed on caribou kills.
Grizzlies, wolves and even eagles predate on caribou in various parts of their range.