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Louse is the root word. The plural is 'Lice'. Unclean, unkempt persons can become infested with lice which are parasites and live off the person by sucking blood and/or eating skin cells. This tends to make the person feel ill and the term 'feeling lousy' (sometimes spelled 'lousey') came from this condition.

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Q: What is the root word for lousy?
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