The U.K.'s Last of the Summer Wine ran from 1973 to 2010 and had 295 episodes.
However, if you include animated programs, The Simpsons leads the way with 23 seasons w/ 508 episodes with (as of 09/2012) 2 more seasons worth of episodes left.
Jerry SeinfeldHe appeared as Frankie in three episodes that aired in 1980.
The ABC sitcom "Full House" ran for 8 seasons and had 192 total episodes. It ran from September 22, 1987 to May 23, 1995.
Pair of Kings is the name of a sitcom that is shown on the Disney XD channel. It stars Adam Hicks and Doc Shaw. The show ran for 3 seasons and was not renewed for a fourth, so no new episodes will be made.
The successful British sitcom " The IT Crowd" created by Graham Linehan first aired on February third 2006 on channel four. It ran for four seasons of six episodes each.
It ran for 6 seasons, which is pretty long for most animated series's. They probably just ran out of ideas for episodes
The Drew Carey Show
"Bob" ran 33 episodes 1992-1993. He also starred in "George & Leo", which ran 21 episodes 1997-1998.
The Jeffersons ran for 11 seasons, between 1975-1985 with a total of 253 episodes.
Jerry SeinfeldHe appeared as Frankie in three episodes that aired in 1980.
The ABC sitcom "Full House" ran for 8 seasons and had 192 total episodes. It ran from September 22, 1987 to May 23, 1995.
"One of the Boys" (1982). It ran for 13 episodes. It also starred Dana Carvey, Nathan Lane, Scatman Crothers.
Pair of Kings is the name of a sitcom that is shown on the Disney XD channel. It stars Adam Hicks and Doc Shaw. The show ran for 3 seasons and was not renewed for a fourth, so no new episodes will be made.
Mad About You was a popular sitcom that ran for 7 seasons. It was first aired on the 23rd of September 1992, with the final episode being the 24th of May 1999. It ran for 164 episodes in all.
Hogan's Heroes is an American television sitcom that ran for 168 episodes from September 17, 1965, to March 28, 1971, on the CBS network.
The television show "Diff'rent Strokes" was created by Jeff Harris and Bernie Kukoff. The sitcom ran for 8 seasons and produced 189 episodes which aired on the networks of NBC and ABC.
Frasier was a TV sitcom that initially aired on NBC from 1993 to 2004, and ran for 11 seasons. One can find information about episodes from IMDb, as well as a plethora of fan sites where each episode is discussed in great details.
The successful British sitcom " The IT Crowd" created by Graham Linehan first aired on February third 2006 on channel four. It ran for four seasons of six episodes each.