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Changing one amino acid with a protein could change what about the protein?
Wiki User
∙ 14y ago
It will depend on how different the amino acid is to the one it replaced. If the structure and/or charge is quite different, a change of one amino acid can change the entire 3D structure of the protein. This will affect the proteins function.
Wiki User
∙ 12y ago
Wiki User
∙ 14y agoEven though polypeptides can be thousands of amino acids long, a single replacement of one amino acid with another could make the protein ineffective and/or harmful to the organism. Sickle-cell disease is caused by just one amino acid that is omitted for another, yet the consequences are great indeed. Proteins are shaped for their function, for example, a protein that aids in defense might have a shape that is conducive to engulfing foreign bacteria. But if the sequence in the primary structure is even a little bit off, the shape will be altered and the protein will not be able to do its job.
Wiki User
∙ 14y agoThe primary structure of the protein would be changed, the tertiary structure of the protein might be changed, and the biological activity or function of the protein might be altered
Wiki User
∙ 12y agoProtein is changed and can't perform its normal function .
Wiki User
∙ 7y agoIf the amino acids are different, then the protein will be different
Wiki User
∙ 14y agoits ability to function
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Can changing just one nucleotide in a gene change the shape of a protein?
If shape of a protein is changed its function is altered. This might change or stop a particular biochemical pathway in which that enzyme was critical. Specific 3D shape of each protein is very essential for its function. Change in shape of proteins is caused by a mutation in the DNA.
How could error during transcription affect the protein that produced?
The protein would be made of the wrong amino acids
Why would a change in your amino acid cause your enzyme to lose it's function?
By changing the amino acids, you may have also changed the pH of them and enzymes will only work at a certain pH level. This level is different for different enzymes. So the amino acids may well have denatured the enzymes.
What happens if you change a single base in codon?
If one base in a codon was changed, this would be a point mutation. This may not cause any change in the structure of the protein, or it could be severely damaging. Since most amino acids have more than one codon, it's possible that the mutation would result in one of the other codons for that amino acid. In that case, there would be no change in the sequence of amino acids, and no change in the structure or function of the protein. A point mutation might also result in a codon that codes for a totally different amino acid, which can cause a genetic disorder. One example of a genetic disorder caused by a point mutation is sickle cell anemia. It's also possible that the point mutation could cause the codon to code for a stop signal. Please read the article in the related links for more information.
How may or may not a mutation in the DNA sequence of a gene affect the expression of the gene or the sequence of amino acids in the encoded protein?
only a single amino acid could change, because the reading frame is unaffected.
How a change in the sequence of nucleotides in a strand of DNA might cause a protein to malfunction?
The sequence of nucleotides is altered and therefore, the amino acid that is to be added to the peptide chain will be altered. hence the protein will be different. This protein can be functionless (will be degraded). If it turns out to be toxic, then there may be symptoms.
What type of mutation in the DNA leads to a single change in the amino acid sequence of the protein?
Yes, it already has by changing the amino acid you have a mutation. That one amino acid counld be in the active site of an enzyme and that one amino acid being changed could result in loss of function or reduction in function of the enzyme. Sickle cell animea is caused by a single such amino acid substiution.
Can changing just one nucleotide in a gene change the shape of a protein?
If shape of a protein is changed its function is altered. This might change or stop a particular biochemical pathway in which that enzyme was critical. Specific 3D shape of each protein is very essential for its function. Change in shape of proteins is caused by a mutation in the DNA.
What impact could a point mutation do?
A point mutation could have no impact or it could be lethal. It depends on whether the mutation changes the amino acid sequence of a protein, or if it changes the amino acid at a critical location in the protein.
How does the sequence of DNA affect the function of a protein?
The sequence of nucleotides in DNA molecule is equivalent and is closely related to an amino acid sequence in the protein molecule. If for any reason the sequence of DNA nucleotides changes it will be reflected in amino acid sequence in the protein. Moreover, the correct sequence of amino acid in the protein will form the correct three-dimensional structure, or tertiary structure, that will confer the biological activity to protein. If a wrong amino acid is translated from a mutated gene in the DNA could change the spatial structure of the protein and therefore modify or erase its biological function.
Why does mrna mutation affect the amino acid sequence?
The codon UGU codes for the amino acid Cysteine. The codon UGG codes for the amino acid Tryptophan. Therefore the mutation will cause the amino acid Cysteine to be replaced with Tryptophan. These amino acids are quite different, and the final shape of the protein could be changed as a result. This could affect the function of the protein.
How could error during transcription affect the protein that produced?
The protein would be made of the wrong amino acids
Could a compound that contains carbon hydrogen and oxygen be a protein?
No, proteins are chains consisting of amino acids. Amino acids contain nitrogen.
Why would a change in your amino acid cause your enzyme to lose it's function?
By changing the amino acids, you may have also changed the pH of them and enzymes will only work at a certain pH level. This level is different for different enzymes. So the amino acids may well have denatured the enzymes.
Why would an insertion or deletion mutation have more effect than a substitution mutation?
Base-pair insertions have a greater effect because they shift the information on the DNA down and change all following information, whereas substitutions may change only one amino acid or have no effect. -The base-pairs code for amino acids in groups of three. If just one base is added in, then this grouping is shifted upstream by one. The incorrect amino acids will be coded for and added to the protein being built. It could possibly stop the protein from being synthesized fully if the change creates a stop codon. This usually hinders the protein from functioning. -Base-pair substitution mutations only affect the codon (set of 3 base pairs) that it actually occurs in. If the mutation is in the first base-pair of the codon then the amino acid will change. If the mutation is in the second or third position of the codon then amino acid may or may not change; this is because amino acids can be coded for by more than one codon, but the first base-pair (and sometimes the second) is usually the same. A substitution can also change a codon to a stop codon. This may keep the amino acid the same, change only one amino acid (which does not always stop the protein from working), or cause the protein to prematurely stop being built.
What happens if you change a single base in codon?
If one base in a codon was changed, this would be a point mutation. This may not cause any change in the structure of the protein, or it could be severely damaging. Since most amino acids have more than one codon, it's possible that the mutation would result in one of the other codons for that amino acid. In that case, there would be no change in the sequence of amino acids, and no change in the structure or function of the protein. A point mutation might also result in a codon that codes for a totally different amino acid, which can cause a genetic disorder. One example of a genetic disorder caused by a point mutation is sickle cell anemia. It's also possible that the point mutation could cause the codon to code for a stop signal. Please read the article in the related links for more information.
Which could not be a compound from which a protein could be directly formed 1. polypeptide 2. amino acid 3. oil or 4. dipeptide?
Oil could not be a compound from which a protein could be directly formed. Proteins are formed from amino acids, which are then linked together to form polypeptides and ultimately proteins. Oil is a different type of organic compound and does not contain the necessary building blocks for protein synthesis.
