March 20,1852
Harriet Beecher Stowe wrote Uncle Tom's Cabin.
The publishing company, National Era and John P. Jewett and Company, was located in Boston, so Massachusetts would be my best guess.
Uncle Tom's Cabin by Harriet Beacher Stowe was published on March 20, 1852 in the USA by both National Era and John P. Jewett and Company.
To raise awareness for slaves in the south.