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if starting in San Frasciso area take Rt 80, if farther south you may have to take 70. If on 70, when you hit Denver take 76 northeast and pick up 80 around the corner of Colorado and Nebrask, then take 80 east and you'll end up just south of Chicago (Lake Michigan) and can continue onto Cleveland (Lake Erie) and then go up to Rt 90/Buffalo NY and continue onto Lake Ontario just after Niagara falls (which the only way to see is by taken one of the helicopter tours).

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Q: Which highway should you take if you want to start on the pacific coast cross the rocky mountains cross the Mississippi river travel near the the great lakes?
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