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The only difference between these two pills is the amount of acetaminophen (Tylenol) contained within. As to which one is more effective, it can depend on what kind of pain you have. If it is an 'inflammatory' type of pain that Tylenol works really well against, more Tylenol (10/500) would be better. On the other hand, some people report that the hydrocodone is more effective with less Tylenol, and prefer the 10/325 combination instead. I believe the phrase "More killer, less filler" is used to express this preference :)

Hope that helps!

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12y ago
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11y ago

Hydro 10-325 means the pill has 10mgs of hydroocodone in it and 325mgs of acetaminophen in it per pill and the 10-500 has 10 mgs of hydrocodone and 500 mgs of acetaminophen in it per pill and they last longer and are considered stronger than the 325mg pills.

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12y ago

10-325s. 10 or the 5 value is your narcotic value.

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Layla Grant

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2y ago
help my

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11y ago

One has 325 mg. Acetaminophen, while the other contains 500 mg.

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11y ago

10-325 is twice as much as 5-325.

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12y ago

10 325

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Q: Which is more effective for pain 10 mg hydrocodone with 500 acetaminophen or 10 mg with 325 mg of acetaminophen?
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