Alan B Scott, MD, an ophthalmologist and founder of the Smith-Kettlewell Eye Research Institute in San Francisco, first developed and manufactured Botulinum Type A neurotoxin (BTX-A) for therapeutic use in eye muscles. Originally trade-named "Oculinum", it was rebranded "Botox" when rights were sold to Allergan, which developed it as a cosmetic. Scott first reported that BTX-A could weaken selected eye muscles in monkeys in 1973, and was clinically useful to treat human strabismus in 1980.
Strabismus is misalignment of the eyes caused by imbalances in the actions of muscles that rotate them. Regardless of cause, balance can sometimes be restored by weakening a muscle that pulls too strongly, or pulls against one that has been weakened by disease or trauma. BTX-A prevents neurotransmitter release from neuromuscular junctions, and so at least partially paralyzes injected muscles. The paralytic effect is temporary, and it might seem that injections would always need to be repeated, except that muscles adapt to the lengths at which they are chronically held, so that a muscle paralyzed by BTX-A tends to get stretched-out by its antagonist (if there is one) and grow longer, while the antagonist tends to grow shorter. This can lead to a permanent re-alignment, even when BTX-A-caused paralysis has resolved.
Scott wanted to treat strabismus without surgery or general anesthesia, but the 6 muscles of an intact eye lie deep in the orbit and are hardly visible, so how could the desired muscle alone be injected? Scott solved this problem by developing EMG-guided injection: the hypodermic needle used to inject the toxin would also function as an electrode that recorded the activity (the electromyogram or EMG) of the muscle in which its tip was embedded. Patients would need to be awake during the procedure. The needle would be introduced, and as the patient looked in different directions, the pattern of muscle activity, played through a speaker, would indicate when the belly of the targeted muscle had been entered, and the toxin would be injected.
To appreciate the genius of Scott's work, consider that even a mind capable of working out the medical, pharmacological, and practical aspects of such a non-obvious procedure, and its safe application, would likely flee, early on, from thoughts of pushing a hypodermic needle deep alongside the healthy eye of an awake patient, without visual guidance, for the purpose of injecting the most acutely toxic substance known.
1976 that when it was first invented P's. i am going to kill myself
No, Botox is not a steroid. Botox is a neurotoxin that is used for both medical and cosmetic purposes.
Yes she did have botox.
100 units of Botox = 4ml, therefore 25 units of Botox = 1ml and 5,000 units of Botox would equal 5,000/25 = 200ml of Botox
No. Prince never do botox.
BOTOX! She has procedures tri-yearly, and botox among anything she can find to inject herself with.
Botox don't contain silicon.
botox cause cancer yes or no
You can inject botox anywhere in the human body. But, given that botox is highly toxic it would not be a smart thing to do.
A patient who just had botox should not rub the area where the botox was performed, should not bend the head down, and also should not exercise the same day as the botox. Additionally, the area where the botox was performed should be iced to decrease bruising or swelling.
The amount of botox in a 20SIZE injection varies depending on the brand and type of botox being used. Generally, a 20SIZE injection contains between 100 and 200 units of botox. This can be broken down into the following: 1.0cc = 25 units of botox 2.0cc = 50 units of botox 4.0cc = 100 units of botox 8.0cc = 200 units of botoxIt is important to note that the amount of botox needed in an injection can vary depending on the individual, so it is important to consult with a qualified medical professional before receiving a botox injection.
In 2009 4,795,357 Botox procedures were performed.