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The female voice is.... Elizabeth Daily. She is also the voice of Tommy Pickles on Rugrats and Buttercup on Powerpuff Girls. http://www.imdb.com/title/tt0369179/trivia

"At a convention of television critics during the summer of 2005, executive producer Chuck Lorre confirmed that the show's opening tune is performed by studio musicians and not by actors Charlie Sheen, Jon Cryer and Angus T. Jones (who merely lip-sync the lyrics). One of the actual crooners is singer and voice-over artist Elizabeth Daily."

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Q: Who is the female singer in the theme song Two and a half men?
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