His brother, Mycroft.
Sherlock Holmes had one brother. His name was Mycroft Holmes. He was smarter than Sherlock, but did not like moving around the way Sherlock always did.
Sherlock Holmes's grandmother was the sister of the French painter, Vernet.
Towards the beginning of 'The Adventure of the Norwood Builder' we find this passage:
At the time of which I speak, Holmes had been back for some months, and I, at his request, had sold my practice and returned to share the old quarters in Baker Street. A young doctor, named Verner, had purchased my small Kensington practice, and given with astonishingly little demur the highest price that I ventured to ask - an incident which only explained itself some years later, when I found that Verner was a distant relation of Holmes', and that it was my friend who had really found the money.
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The fictitional Holmes never married. There is no mention of any offspring.
Sherlock Holmes was not married and had no children.
He was never married in any of the stories and had no children.
It is not likely that Sherlock Holmes ever had a child.
It appeared that his only friend was really Dr. Watson. He had a very large set of acquiantances from which he drew specialized knowledge and services.
Harold Stackhurst (The Adventure of the Lion's Mane) was an acquaintance later in life. His brother Mycroft could be considered a friend. In 'The Gloria Scott' Holmes speaks of a friendship with Victor Trevor in college. In 'The Musgrave Ritual' Holmes speaks of an acquaintance with Reginald Musgrave in college. I am certain there were others who Watson never saw fit to mention.
We learn in 'The Sign of Four' that Watson had at least one older brother H. Watson who likely had recently passed away. Watson's brother and father had the same first initial, and it is likely the 'H' is the same name for all three Watsons.
He has a brother: Mycroft, even more gifted than Sherlock but lacking the energy of the famous Sherlock.
The only relative in the stories is his brother, Mycroft. Watson is his friend, but he had many acquaintances.
Sherlock Holmes' real name is Sherlock Holmes.
Sherlock Holmes
Robert Downey jr has been in two Sherlock Holmes movies: Sherlock Holmes (2009) and Sherlock Holmes: A Game of Shadows (2011)
Sherlock & Holmes
The Adventures of Sherlock Holmes