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Why does alcohol abuse increase tolerance to other drugs such as barbiturates?
Wiki User
∙ 13y ago
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Enzymes of the smooth ER help detoxify drugs and poisons, especially in liver cells. Detoxification usually involves adding hydroxyl groups to drugs, making them more soluble and easier to flush from the body. The sedative phenobarbital and other barbiturates are examples of drugs metabolized in the manner by smooth ER in liver cells. In fact, barbiturates, alcohol, and many other drugs induce the proliferation of the smooth ER and its associated detoxification enzymes. This, in turn, increases tolerance to the drugs, meaning that higher doses are required to achieve a particular affect, such as sedation. Also, because some other the detoxification enzymes have relatively broad action, the proliferation of the smooth ER in response to one drug can increase tolerance to other drugs as well. Barbiturate abuse, for example, may decrease the effectiveness of certain antibiotics and other useful drugs.
Wiki User
∙ 13y ago
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Is respiratory increase a symptom of alcohol abuse?
No
How much alcohol do you have to drink until you abuse it?
Every persons tolerance is different. I don't think anyone who is 21+ should have more than one or two shots of alcohol.
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it can make you drowsy. plus it has a high potential for abuse,
Which one isn't a symptom of alcohol abuse coma loss of body heat respiratory increase speech disruption motor disruption?
Respiratory increase
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99.9% of spouse abuse is caused by alcohol abuse.
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Alcohol and drugs impair one's ability to use good judgment and make competent, well thought out decisions.
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alcohol abuse
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42% of animal abuse was involved with alcohol in 2005.
What has the author Jack E Henningfield written?
Jack E. Henningfield has written: 'Barbiturates' -- subject(s): Barbiturates, Drug abuse, Drugs, Juvenile literature, Toxicology 'Nicotine Old-Fashione'
Can alcohol cause Alcohol abuse and alcoholism?
Yes anxiety is very common and even inevitable in those who abuse alcohol and or drugs.
How does tolerance for drugs lead to abuse or overdose?
Tolerance requires higher and higher doses to achieve the original effects.
Is alcohol abuse a stress related illness?
Alcohol abuse is not an illness but a behavior. The same is true of alcoholism.
