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Why does dilantin have a smaller retention time in reversed phase HPLC as compared to benzil?

In: Health, Medication and Drugs [Edit categories]

Answer:

My guess is that it is because Dilantin has two benzyl substituents on one carbon, adding steric hindrance. Second, the ring is very electron deficient, and so unstable. Benzil has less steric hindrance and is linear.

First answer by ID1276394517. Last edit by ID1276394517. Question popularity: 1 [recommend question].

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