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Think about measures at 3 different time points: when the action potential (AP) crosses the first electrode, when it hits the point of damage, and if undamaged when it crosses the 2nd electrode. You're always measuring the difference between 2 electrodes, R1 and R2.

1. When the AP crosses only the first, you see half of the biphasic profile. In math terms, R1 is larger than R2 and R1 - R2 = AP.

2. When it hits the damage point, the AP stops, since it requires functional biological nerve to propagate. No AP at the first and no AP at the second means R1 - R2 is effectively zero. When combined with 1, you see a monophasic profile.

3. If there's no damage, the AP hits the 2nd electrode. Since you haven't switched any electrodes, R2 is now measuring the AP, and it's larger than R1. R1 - R2 = -AP = the mirror-imaged, 2nd half of the biphasic profile.

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15y ago

A nerve is crushed between the two recording electrodes.

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Q: Why does the biphasic action potential change into the monophasic action potential after nerve injury between the two recording electrodes?
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