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Yes.

Many chronic or debilitating diseases can affect the body's ability to defend itself from invading microbes like viruses. Some of those are Diabetes Mellitus, chronic obstructive pulmonary disease, cystic fibrosis, Heart disease, liver and kidney disorders, those on chemotherapy or with recent transplants on immune suppressing drugs, asthma, multiple sclerosis, and certainly problems with the function of the immune system. Also at higher risk are the very old and the very young and pregnant women. It also can cause underlying chronic disorders to exacerbate, making recovery more of a struggle.

Proper nutrition, hydration, sleep, vitamin C and rest will be important.

Guarding against exposure to anyone with symptoms of cough, sneeze, fever, shortness of breath or other cold or flu symptoms will be necessary.

If you live in an area where there are reported cases of the swine flu, you may want to consider limiting time out in public. Utilize the best hygiene and hand washing techniques.

See the related question below for additional techniques for preventing infection by viruses or other microbes.

See also related links for additional information about the flu from the CDC.

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Q: Will autoimmune disease increase the chances of getting swine flu?
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