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Niacin, also known as nicotinic acid, is vitamin B3. It occurs naturally in plants and animals and is also added to many foods as a vitamin supplement. Niacin also blocks the production of cholesterol in the body.

Niacin is used to reduce levels of LDL (or "bad") cholesterol, total cholesterol, and triglycerides and to raise levels of "good" (HDL)cholesterol. These actions are important in the prevention of Heart disease and hardening of the arteries, which can lead to heart attacks, stroke, and peripheral vascular disease.

Niacin works by blocking the release of triglycerides from storage (body fat) and also by inhibiting the liver from making more from blood sugar by blocking hepatocyte diacylglycerol acyltransferase.

Update: more details on how niacin raises HDL have been reported by

Lin-Hua Zhang, Vaijinath S. Kamanna, Michael C. Zhang, and Moti L. Kashyap. Niacin inhibits surface expression of ATP synthase %u03B2 chain in HepG2 cells: implications for raising HDL. J. Lipid Res, 49: 1195-1201 (June 2008)

From the press release:

"The researchers focused on a certain component in ATP synthase, the protein that makes the body's energy source ATP. A subunit of the protein known as the 'beta chain' can take up HDL, and therefore reduce the body's levels of 'good' cholesterol.

Using human cells, Moti Kashyap and colleagues found that this beta chain is the basis of niacin's effect. When human liver HepG2 cells were incubated with niacin a 27 per cent reduction in the presence of beta chains on the cell surface was observed.

Moreover, a 35 per cent reduction in the uptake of HDL was recorded."

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11y ago
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6y ago

yes niacin lower cholesterol

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Q: Can niacin lower cholestrol
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