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You cannot eat grapefruit while taking methadone because certain organic compounds in the grapefruit will inhibit certain enzymes in your intestine and, to a lesser extent, your liver. This means that because there are less of these enzymes floating around to break down the methadone, more of that methadone is in your bloodstream. Thus a toxic level may build up, rendering you dead from an opiate overdose.

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Q: Why cant you eat grapefruit while taking methadone?
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