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The difference between the first and second line of defence is that the first line of defence is your physical barrier like your skin and it protects you from most pathogens entering your body and the sweat and oil on your skin prevent some pathogens from growing on your body. the second line of defence is when a pathogen makes it past the first line of defence your body can mount an immune response to the attack and destroy the invader. Whether or not the response succeeds depends very much on your body's ability to distinguish between cells that belong to it and cells that do not.

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12y ago
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10y ago

Innate Immune Respose and Aquired Immune Response.... ^_^

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11y ago

difference is the

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Q: What is the difference between the first and second line of defense in the immune system?
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