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Taken together, there might be additional central nervous system and respiratory system depression, which could be bad. I personally think that the combination is quite enjoyable (it's prescribed by my doctor). They seem to achieve a kind of synergy, with the hydrocodone being potentiated (working better), and the lunesta effects being transformed subtly into the feeling of a rather large dose or valium.

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Q: What is the side effect of taking lunesta with hydrocodone?
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